涓浗绉戝瀹惰В鏋愰潪娲茬尓鐦熺梾姣掑叧閿叾缁撴瀯

   yekai   瑙傚療鑰呯綉    2019-11-01 19:02:26
銆愬璇汇€戞嵁涓闄㈢綉绔�11鏈�1鏃ユ秷鎭紝10鏈�29鏃ワ紝涓浗绉戝闄㈠井鐢熺墿鐮旂┒鎵€楂樼鍥㈤槦鍦ㄥ井鐢熺墿鐮旂┒鏈熷垔mBio 鍦ㄧ嚎鍙戣〃浜嗛涓篊rystal Structure of African Swine Feve...

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dUTP鐒︾7閰搁叾锛坉UTPase锛夋槸DNA鍚堟垚涓殑涓€绉嶅叧閿叾锛屽箍娉涘垎甯冧簬鐪熸牳銆佸師鏍哥粏鑳炰互鍙婄梾姣掔瓑鐢熷懡鏈夋満浣撳唴銆傝閰惰兘澶熸按瑙g粏鑳炶川涓殑dUTP锛屼粠鑰屾渶澶ч檺搴﹀湴鍑忓皯灏垮槯鍟跺湪DNA鍚堟垚涓殑閿欒鎻掑叆锛岄檷浣庣粏鑳炰腑dUTP/dTTP鐨勬瘮渚嬶紝缁存寔鍩哄洜缁勫鍒剁殑淇濈湡搴﹀拰椤哄埄杩涜銆侫SFV涔熺紪鐮佽繖绉嶉叾锛岀О涓篍165R銆傜爺绌朵汉鍛樿В鏋愪簡apo-E165R鍜孍165R-dUMP澶嶅悎浣撶殑鏅朵綋缁撴瀯锛屼负闈跺悜E165R鐨勬姉ASFV鑽墿璁捐鎻愪緵浜嗛噸瑕佷緷鎹€�

涓浗绉戝瀹惰В鏋愰潪娲茬尓鐦熺梾姣掑叧閿叾缁撴瀯

涓浗绉戝瀹惰В鏋愰潪娲茬尓鐦熺梾姣掑叧閿叾缁撴瀯

ASFV E165R涓巇UMP鐨勫鍚堢墿缁撴瀯 鍥捐嚜涓闄㈢綉绔�

閫氳繃瑙f瀽apo-E165R鍜孍165R-dUMP澶嶅悎浣撶殑鏅朵綋缁撴瀯锛屽垎鏋愮‘瀹氫簡閰舵椿鎬т綅鐐圭殑缁撴瀯锛屼互鍙婁笌閰嶄綋dUMP涔嬮棿鐨勭浉浜掍綔鐢ㄤ綅鐐癸紙鍥�1锛夈€傝繘涓€姝ラ€氳繃姣斿ASFV-E165R涓庡叾瀹冪墿绉嶇殑dUTPase鐨勭粨鏋勶紝鍙戠幇E165R鐨勬椿鎬т綅鐐逛笌缁撴牳鍒嗘灊鏉嗚弻鍜屾伓鎬х枱鍘熻櫕鐨刣UTPase鐨勬椿鎬т綅鐐归珮搴︾浉浼硷紙鍥�2锛夈€傝€岀粨鏍稿垎鏋濇潌鑿屽拰鎭舵€х枱鍘熻櫕鐨刣UTPase宸茶璇佹槑鑳藉浣滀负鑽墿璁捐鐨勯澏鐐癸紝濡偽�,尾-imido-dUTP锛坉UPNPP锛夊凡琚敤鏉ユ姂鍒剁粨鏍稿垎鏋濇潌鑿岀殑dUTPase娲绘€э紱涓€浜涜劚姘у翱鑻蜂笁鑻熀鐢茬兎琛嶇敓鐗╀篃琚彂鐜板叿鏈夋姉鐤熸椿鎬с€傚洜姝ら拡瀵笰SFV-E165R娲绘€т綅鐐瑰紑鍙戠殑灏忓垎瀛愬寲瀛﹁嵂鐗╁緢鍙兘瀵笰SFV鏈夋晥銆傜爺绌剁粨鏋滀负闈跺悜E165R鐨勬姉ASFV鑽墿璁捐鎻愪緵浜嗛噸瑕佷緷鎹€�

涓浗绉戝瀹惰В鏋愰潪娲茬尓鐦熺梾姣掑叧閿叾缁撴瀯

涓浗绉戝瀹惰В鏋愰潪娲茬尓鐦熺梾姣掑叧閿叾缁撴瀯

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鏇村鏈夊叧 猪瘟

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    鎹腑绉戦櫌缃戠珯11鏈�1鏃ユ秷鎭紝10鏈�29鏃ワ紝涓浗绉戝闄㈠井鐢熺墿鐮旂┒鎵€楂樼鍥㈤槦鍦ㄥ井鐢熺墿鐮旂┒鏈熷垔mBio 鍦ㄧ嚎鍙戣〃浜嗛涓篊rystal Structure of African Swine Fever Virus dUTPase Reveals a Potential Drug Target 鐨勬枃绔狅紝鍦ㄩ潪娲茬尓鐦熺梾姣掑叧閿叾缁撴瀯瑙f瀽涓庤嵂
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  • 鐚満闈炴床鐚槦鍚庡浜х殑鍏抽敭鐢熶骇鐐�

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  • 鍐滄潙鍦熺尓浼氫紶鏌撻潪娲茬尓鐦熷悧锛�

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    鎹腑绉戦櫌缃戠珯11鏈�1鏃ユ秷鎭紝10鏈�29鏃ワ紝涓浗绉戝闄㈠井鐢熺墿鐮旂┒鎵€楂樼鍥㈤槦鍦ㄥ井鐢熺墿鐮旂┒鏈熷垔mBio 鍦ㄧ嚎鍙戣〃浜嗛涓篊rystal Structure of African Swine Fever Virus dUTPase Reveals a Potential Drug Target 鐨勬枃绔狅紝鍦ㄩ潪娲茬尓鐦熺梾姣掑叧閿叾缁撴瀯瑙f瀽涓庤嵂
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